bet356体育在线育 - bet356手机体育专任教师简介-陈和平

陈和平

54

中国

汉族

江西金溪

教授

教研室主任

导师类型

博士生导师

电子邮箱

chenheping@ncu.edu.cn.com

主讲

课程

药理学、药物毒理学、生物制药学

研究

方向

主要研究方向为心血管药理学,重点围绕心肌缺血损伤与保护的新靶向分子发现、新作用机制等研究

教育

经历

2001~2004,江西医学院,研究生/硕士,药理学专业

2006~2009,中山大学,bet356体育在线育 - bet356手机体育,研究生/博士,药理学专业

工作

履历

2004.7~2009.10,南昌大学,bet356体育在线育 - bet356手机体育,讲师

2009.11~2014.11,南昌大学,bet356体育在线育 - bet356手机体育,副教授

2014.12~至今,南昌大学,bet356体育在线育 - bet356手机体育,教授

学术

兼职

中国药理学会麻醉药理专业委员会委员

江西省细胞生物学学会理事

江西省基础药理学专业委员会常务委员

国家自然科学基金项目通讯评审专家

个人

荣誉

2015年南昌大学215工程赣江特聘教授;

2011年江西省高等学校中青年骨干教师;

主要业绩

一、 主要科研成果

主持国家自然科学基金项目五项、主持江西省自然科学基金重点项目一项、主持江西省自然科学基金面上项目两项、主持教育厅资助项目一项。发表学术论文40余篇(其中以第一作者或通讯作者发表SCI论文29篇)、参编教材2部。

1、 主持科研课题:

[1] “心肌缺血再灌注过程中DJ-1蛋白C106位点氧化状态与细胞自噬二重性间关系及其机制研究”(国家自然科学基金,№:32160213,起止年月:2022.1~2025.12,陈和平主持)

[2] “基于DJ-1-Grp75-线粒体复合体Ⅰ调控途径探讨DJ-1介导心肌缺血预适应延迟保护的新机制”(国家自然科学基金,№:81460060,起止年月:2015.1~2018.12,陈和平主持)。

[3] “油茶皂苷上调AE3表达及其通过AE3调控缺血/再灌注心肌细胞内Cl-外流与线粒体保护机制研究”(国家自然科学基金,№:81260419,起止年月:2013.1~2016.12,陈和平主持)。

[4] “DJ-1通过Nrf2-ARE抗氧化通路参与心肌缺血预适应延迟保护的研究”(国家自然科学基金,№:81060022,起止年月:2011.1~2013.12,陈和平主持)。

[5] “AE3介导的油茶皂苷抗急性心肌损伤作用及其机制”(国家自然科学基金,№:30660209,起止年月:2007.1~2009.12,陈和平主持)

[6] “基于DJ-1/mtHsp70/线粒体复合酶Ⅰ/mtROS调控途径探讨白藜芦醇抗心肌缺血再灌注氧化应激损伤的新机制”(国家自然科学基金,№:81960586,起止年月:2020.1~2023.12,陈和平第二参与)

[7] “白藜芦醇促缺血/再灌注心肌细胞内DJ-1线粒体亚定位保护复合酶Ⅰ活性的分子机制研究” (江西省自然基金项目,№:20192BAB205116,起止年月:2019.6~2022.6,陈和平主持)

[8] “DJ-1在心肌缺血再灌注自噬双重性中的调控作用及机制探讨” (江西省自然科学基金重点项目,№:20202ACB206012,起止年月:2021.1~2024.12,陈和平主持)

[9] “DJ-1在心肌缺血预适应延迟保护中的作用及其机制研究”(江西省自然基金项目,№:2010GZY0220,起止年月:2011.1~2013.12,陈和平主持)。

[10] “RNAi沉默AE3对心肌缺血再灌注损伤的影响”(江西省教育厅项目,№:GJJ09085,起止年月:2009.1~2011.12,陈和平主持)。

[11] “14-3-3η/PKCε交互作用与心肌缺血保护作用”(973前期研究专项,№:2009CB526405,起止年月:2009.5~2011.8,陈和平参与)。

2、发表代表性论文:

[1] Liu S, Xu S, Liu S, Chen H(通讯作者). Importance of DJ-1 in autophagy regulation and disease. Arch Biochem Biophys. 2023 Jul 15;743:109672.

[2] Liu S, Ren J, Liu S, Zhao X, Liu H, Zhou T, Wang X, Liu H, Tang L, Chen H(通讯作者). Resveratrol inhibits autophagy against myocardial ischemia-reperfusion injury through the DJ-1/MEKK1/JNK pathway. Eur J Pharmacol. 2023 Jul 15;951:175748.

[3] Zhao XY, Ren JM, Liu HR, Zhou TT, Wang XY, Liu S, Chen HP(通讯作者). DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury. Biochem Biophys Res Commun. 2022 Dec 31;637:276-285.

[4] Qiu LJ, Ma ZX, Li XR, Deng YZ, Duan GL, Xu XW, Xiao, Liu HY, Zhu ZM, Chen HP(通讯作者). DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway. Acta Biochim Biophys Sin. 2020 Dec 11;52(11):1202-1214..

[5] Zhou TT, Wang XY, Huang J, Deng YZ, Qiu LJ, Liu HY, Xu XW, Ma ZX, Tang L, Chen HP(通讯作者). Mitochondrial translocation of DJ-1 is mediated by Grp75: implication in cardioprotection of resveratrol against hypoxia/reoxygenation-induced oxidative stress. J Cardiovasc Pharmacol. 2020 April; 75(4):305-313.

[6] Deng YZ, Xiao L, Zhao L, Qiu LJ, Ma ZX, Xu XW, Liu HY, Zhou TT, Wang XY, Tang L, Chen HP(通讯作者). Molecular Mechanism Underlying Hypoxic Preconditioning-Promoted Mitochondrial Translocation of DJ-1 in Hypoxia/Reoxygenation H9c2 Cells. Molecules. 2020;25(1). pii: E71.

[7] Liu HY, Duan GL, Xu RY, Li XR, Xiao L, Zhao L, Ma ZX, Xu XW, Qiu LJ, Zhu ZM, Chen HP(通讯作者). DJ-1 overexpression confers the multidrug resistance phenotype to SGC7901cells by upregulating P-gp and Bcl-2. Biochem Biophys Res Commun. 2019 Oct 29;519(1):73-80.

[8] Xu RY, Xu XW, Deng YZ, Ma ZX, Li XR, Zhao L, Qiu LJ, Liu HY, Chen HP(通讯作者). Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway. Biochem Biophys Res Commun. 2019 Jun 25;514(2):401-406.

[9] Ding H, Xu XW, Wang H, Xiao L, Zhao L, Duan GL, Li XR, Ma ZX, Chen HP(通讯作者). DJ-1 plays an obligatory role in the cardioprotection of delayed hypoxic preconditioning against hypoxia/reoxygenation-induced oxidative stress through maintaining mitochondrial complex I activity. Cell Biochem Funct. 2018 Apr;36(3):147-154..

[10] Zhang Y, Li XR, Zhao L, Duan GL, Xiao L, Chen HP(通讯作者). DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol-mediated cardioprotection against hypoxia/reoxygenation-induced oxidative stress. Biomed Pharmacother. 2018 Feb;98:545-552.

[11] Zhang Y, Li Z, Fan X, Xiong J, Zhang G, Luo X, Li K, Jie Z, Cao Y, Huang Z, Wu F, Xiao L, Duan G, Chen H(共同通讯作者). PRL-3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway in vitro and in vivo. Oncol Lett. 2018 Jun;15(6):9069-9074.

[12] Qiu LY, Duan GL, Yan YF, Li YY, Wang H, Xiao L, Liao ZP, Chen HP(通讯作者). Sasanquasaponin induces increase of Cl/HCO3exchange of anion exchanger 3 and promotes intracellular Clefflux in hypoxia/reoxygenation cardiomyocytes. Mol Med Rep. 2017 Sep;16(3):2953-2961.

[13] Wang H, Li YY, Qiu LY, Yan YF, Liao ZP, Chen HP(通讯作者). Involvement of DJ1 in ischemic preconditioninginduced delayed cardioprotection in vivo. Mol Med Rep. 2017 Feb;15(2):995-1001.

[14] Li YY, Xiao L, Qiu LY, Yan YF, Wang H, Duan GL, Liao ZP, Chen HP(通讯作者). Sasanquasaponin-induced cardioprotection involves inhibition of mPTP opening via attenuating intracellular chloride accumulation. Fitoterapia. 2017 Jan;116:1-9.

[15] Zhang XG, Zhao L, Li YY, Wang H, Duan GL, Xiao L, Li XR, Chen HP(通讯作者). Extracellular Cl--freeinduced cardioprotection against hypoxia/ reoxygenation is associated with attenuation of mitochondrial permeability transition pore. Biomed Pharmacother. 2017 Feb;86:637-644

[16] Qiu LY, Chen HP(通讯作者), Yan YF, Li YY, Wang H, Liao ZP, Huang QR. Sasanquasaponin promotes cellular chloride efflux and elicits cardioprotection via the PKCε pathway. Mol Med Rep. 2016 Apr;13(4):3597-603.

[17] Xiong J, Li Z, Zhang Y, Li D, Zhang G, Luo X, Jie Z, Liu Y, Cao Y, Le Z, Tan S, Zou W, Gong P, Qiu L, Li Y, Wang H, Chen H(共同通讯作者). PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. Oncol Rep. 2016 Oct;36(4):1819-28.

[18] Yan YF, Chen HP(通讯作者), Huang XS, Qiu LY, Liao ZP, Huang QR. DJ-1 Mediates the Delayed Cardioprotection of Hypoxic Preconditioning Through Activation of Nrf2 and Subsequent Upregulation of Antioxidative Enzymes. J Cardiovasc Pharmacol. 2015 Aug;66(2):148-58.

[19] Li D, Li Z, Xiong J, Gong B, Zhang G, Cao C, Jie Z, Liu Y, Cao Y, Yan Y, Xiong H, Qiu L, Yang M, Chen H, Jiang S, Yang X, Chen H(共同通讯作者). MicroRNA-212 functions as an epigenetic-silenced tumor suppressor involving in tumor metastasis and invasion of gastric cancer through down-regulating PXN expression. Am J Cancer Res 2015;5(10):2980-2997.

[20] Yan YF, Yang WJ, Xu Q, Chen HP(通讯作者), Huang XS, Qiu LY, Liao ZP, Huang QR. DJ-1 upregulates anti-oxidant enzymes and attenuates hypoxia/re-oxygenation-induced oxidative stress by activation of the nuclear factor erythroid 2-like 2 signaling pathway. Mol Med Rep. 2015 Sep;12(3):4734-42.

[21] Li Z, Zhang G, Li D, Jie Z, Chen H(共同通讯作者), Xiong J, Liu Y, Cao Y, Jiang M, Le Z, Tan S. Methylation-associated silencing of miR-495 inhibit the migration and invasion of human gastric cancer cells by directly targeting PRL-3. Biochem Biophys Res Commun. 2015 Jan 2;456(1):344-50.

[22] Zhu ZM, Li ZR, Huang Y, Yu HH, Huang XS, Yan YF, Shao JH, Chen HP(共同通讯作者). DJ-1 is involved in the peritoneal metastasis of gastric cancer through activation of the Akt signaling pathway. Oncol Rep. 2014 Mar;31(3):1489-97.

[23] Huang XS, Chen HP (通讯作者), Yu HH, Yan YF, Liao ZP, Huang QR. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection. Mol Cell Biochem. 2014 Jan;385(1-2):33-41.

[24] Yu HH, Xu Q, Chen HP(通讯作者), Wang S, Huang XS, Huang QR, He M. Stable overexpression of DJ-1 protects H9c2 cells against oxidative stress under a hypoxia condition. Cell Biochem Funct. 2013 Dec;31(8):643-51.

[25] Zhong YY, Chen HP(通讯作者), Tan BZ, Yu HH, Huang XS. Triptolide avoids cisplatin resistance and induces apoptosis via the reactive oxygen species/nuclear factor‑κB pathway in SKOV3PT platinumresistant human ovarian cancer cells. Oncol Lett 2013;6:1084-1092.

[26] Lu HS, Chen HP(通讯作者), Wang S, Yu HH, Huang XS, Huang QR, He M. Hypoxic preconditioning up-regulates DJ-1 protein expression in rat heart-derived H9c2 cells through the activation of extracellular-regulated kinase 1/2 pathway. Mol Cell Biochem. 2012 Nov;370(1-2):231-40.

[27] Chen HP, He M, Mei ZJ, Huang QR, Huang M. Sasanquasaponin up-regulates anion exchanger 3 expression and elicits cardioprotection via NO/RAS/ERK1/2 pathway. Can J Physiol Pharmacol. 2012 Jul;90(7):873-80.

[28] Chen HP, He M, Mei ZJ, Huang QR, Peng W, Huang M. Anion exchanger 3 is required for sasanquasaponin to inhibit ischemia/reperfusion-induced elevation of intracellular Cl- concentration and to elicit cardioprotection. J Cell Biochem, 2011, 112 (10):2803-12.

[29] Chen HP, Liao ZP, Huang QR, He M. Sodium Ferulate attenuates anoxia/reoxygenation-induced calcium overload in neonatal rat cardiomyocytes by NO/cGMP/PKG pathway. Eur J Pharmacol. 2009, 603 (1-3):86-92.

[30] Chen HP, He M, Huang QR, Zeng GH, Liu D. Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury. Basic Clin Pharmacol Toxicol. 2007, 100(6):366-71.

[31] Chen HP, He M, Xu YL, Huang QR, Zeng GH, Liu D, Liao ZP. Anoxic preconditioning up-regulates 14-3-3 protein expression in neonatal rat cardiomyocytes through extracellular signal-regulated protein kinase 1/2. Life Sci. 2007, 81(5):372-9.

[32] Chen HP, He M, Huang QR, Liu D, Huang M. Sasanquasaponin protects rat cardiomyocytes against oxidative stress induced by anoxia-reoxygenation injury. Eur J Pharmacol. 2007, 575(1-3):21-7.

[33] Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M. Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway. Apoptosis, 2010, 15 (6):693-704.

[34] Liu LL, Yan L, Chen YH, Zeng GH, Zhou Y, Chen HP, Peng WJ, He M, Huang QR. A role for diallyl trisulfide in mitochondrial antioxidative stress contributes to its protective effects against vascular endothelial impairment. Eur J Pharmacol. 2014 Feb 15;725:23-31.

[35] Liao Z, Yin D, Wang W, Zeng G, Liu D, Chen HP, Huang Q, He M. Cardioprotective effect of sasanquasaponin preconditioning via bradykinin-NO pathway in isolated rat heart. Phytother Res, 2009, 23 (8):1146-53.

[36] Huang QR, He M, Chen HP, Shao LJ, Liu D, Luo YM, Dai1 YC. Protective Effects of Sasanquasaponin on Injury of Endothelial Cells Induced by Anoxia and Reoxygenation in Vitro. Basic Clin Pharmacol Toxicol. 2007, 101(5):301-8.

[37] Huang QR, Shao LJ, He M, Chen HP, Liu D, Luo YM, Dai YC. Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in rats. Burns 2005, 31(5):637-42.

[38] He M, Zhang J, Shao L, Huang Q, Chen J, Chen H, Chen X, Liu D, Luo Z. Upregulation of 14-3-3 isoforms in acute rat myocardial injuries induced by burn and lipopolysaccharide. Clin Exp Pharmacol Physiol. 2006, 33 (4):374-80.

[39] Nie C, Gao G, Han J, Li H, Chen HP, He M. Human papillomavirus 16 E6, E7 siRNAs inhibit proliferation and induce apoptosis of SiHa cervical cancer cells. Chinese Journal of Cancer Research, 2008, 20 (4):301-6.

[1] 徐一清,倪晓琳,胡润晖,陈和平(通讯作者). 七氟烷对缺血再灌注心肌的保护作用[J]. 重庆医科大学学报,2018,43(03):317-320.

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