bet356体育在线育 - bet356手机体育专任教师简介-贺永勤

贺永勤

35

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中国

汉族

甘肃平凉

讲师

导师类型

电子邮箱

heyongqin@ncu.edu.cn

主讲课程

药物化学

研究方向

过渡金属催化C-H选择性官能化反应,光催化SP3 C-H键有氧环化反应在药物合成中的应用研究

教育经历

2008-09 2012-06, 河北工业大学, 材料化学, 学士

2012-09 2015-06, 兰州大学, 有机化学, 硕士

2015-09 2017-06, 兰州大学, 有机化学, 博士

2022-12 2023-12, 布里斯托大学,化学院,访问学者

工作履历

2017-07 至今, 南昌大学bet356体育在线育 - bet356手机体育药物化学及天然药物化学教研室专任教师

学术兼职

江西省药学会药物化学专业委员会委员

个人荣誉

2019年南昌大学215工程赣江青年学者

主要业绩

一、 主要科研成果

长期从事过渡金属催化C-H选择性活化研究及光催化有机合成反应研究,发表相关SCI论文20余篇,其中,以通讯作者发表SCI论文3篇,以第一作者及共同第一作者发表SCI论文7篇。作为主要参与者参加国家自然科学基金面上项目3项,以第四作者获江西省科学技术奖二等奖一项

1 主持科研课题:

[1] 南昌大学医学部青年教师科研培育基金项目,4209-16100009-PY201810无导向基参与的喹啉及吡啶C(3)-H选择性官能化反应研究,2019/01-2021/12, 5万元,主持。

[2] 贺永勤. 基于选择性C-H活化策略构建吡啶C3官能团化拟药分子化合物库, 南昌大学创新创业课题, 0.8万元, 2019.1-2020.6, 2020CX251

2、发表代表性论文:

[1] Wan-Fa Tian; Na Li; Zi-He Peng; Li-Hua Feng; Xi Mai; Yong-Qin He* Recent advances in ligand-Promoted transition-metal-catalyzed remote meta-C-H functionalization of arenes, Chin. J. Org. Chem., 2020, 40, 625-644.

[2] Wan-Fa Tian; Ke-Han He; Na Li; Fen Liu; Xi Mai; Li-Hua Feng; Yong-Qin He* Transition-Metal-Free coupling reactions: PPh3-Promoted Sonogashira-Type cross-couplings of heteroaryl halides with terminal alkynes, ChemistrySelect, 2020, 5, 4496-4499.

[3] Liu, Fen; Zhang, Kun.; Zhao, Xiaofei; Meng, Qinxin.; Zhao, Tiansheng.; Tian, Wanfa*; He, Yong-Qin*. Photoinduced stereoselective hydroalkylation of terminal arylalkynes via C(sp3)-H functionalization. Tetrahedron Lett. 2023, 115, 154321.

[4] Yong-Qin He; Zhaoyang Wu; Chaowei Ma; Xiaoqiang Zhou; Xingxing Liu; Xiajun Wang; Guosheng Huang* Palladium-catalyzed selective C-H activation: A simple method to synthesize C-3 site arylated quinoline derivatives, Adv. Synth. Catal., 2016, 358(3), 375-379.

[5] Yong-Qin He; Shengkang Liu; Ping Wen; Wanfa Tian; Xiaoyu Ren; Qiangxiao Zhou; Haojie Ma; Guosheng Huang* Iodine-catalyzed regioselective sulfenylation of indoles with thiols in water, ChemistrySelect, 2016, 1, 1567- 1570.

[6] Xiao-Yu Wang1, Yong-Qin He1, Yi Zhou, Lin Lu, Xian-Rong Song, Zhao-Zhao Zhou, Wan-Fa Tian,* Qiang Xiao* Photoalkylation/-arylation of ortho-Diketones with Unactivated Organic Halides, Org. Lett. 2023, 25, 3847-3852.

[7] Xiao-Yu Wang1, Yong-Qin He1, Mei Wang,a Yi Zhou,a Na Li, Xian-Rong Song, Zhao-Zhao Zhou, Wan-Fa Tian*, Qiang Xiao* Visible-light-driven proton reduction for semihydrogenation of alkynes via organophotoredox/ manganese dual catalysis, RSC Adv., 2022, 12, 36138-36141.

[8] Mei Wang1; Yong-Qin He1; Yao Zhu,; Zhi-Bin Song; Xiao-Yu Wang; Hai-Yang Huang; Ban-Peng Cao; Wan-Fa Tian*; Qiang Xiao* The wavelength-regulated stereodivergent synthesis of (Z)- and (E)-1,4-enediones from phosphonium ylides, Organic Chemistry Frontiers, 2021, 8(21), 5934-5940.

[9] Yao Zhu1; Yong-Qin He1; Wan-Fa Tian*; Mei, Wang; Zhao-Zhao Zhou; Xian-Rong Song; Hai-Xin Ding; Qiang Xiao* Dual cobalt and photoredox catalysis enabled redox-neutral annulation of 2-propynolphenols, Adv. Synth. Catal., 2021, 363(13), 3372-3377.

[10] Wan-Fa Tian1; Yong-Qin He1; Xian-Rong Song; Hai-Xin Ding; Jing Ye; Wen-Jie Guo; Qiang Xiao* cis-Selective transfer semihydrogenation of alkynes by merging visible-light catalysis with cobalt catalysis, Adv. Synth. Catal. 2020, 362, 1032-1038.

[11] Yuxing Fan; Yong-Qin He; Xingxing Liu; Ting Hu; Haojie Ma; Xiaodong Yang; Xinliang Luo; Guosheng Huang* Iodine-mediated domino oxidative cyclization: One-pot synthesis of 1,3,4-oxadiazoles via oxidative cleavage of C(sp2 )-H or C(sp)-H Bond, J. Org. Chem., 2016, 81, 6820-6825.

[12] Zhaoyang Wu; Yong-Qin He; Chaowei Ma; Xiaoqiang Zhou; Xingxing Liu; Yamin Li; Ting Hu; Ping Wen; Guosheng Huang* Oxidative remote C-H trifluoromethylation of quinolineamides on the C5 position with iodobenzene diacetate as the oxidizing agent, Asian J. Org. Chem., 2016, 5, 724-728.

[13] Xiajun Wang, Yong-Qin He; Mengdan Ren, Shengkang Liu, He Liu, and Guosheng Huang*, Pd-catalyzed Ligand-Free Synthesis of Arylated heteroaromatics by Coupling of N-heteroaromatic Bromides with Iodobenzene diacetate, Iodosobenzen or Diphenyliodonium salts, J. Org. Chem., 2016, 81, 7958.

[14] Jian Li, Yong-Qin He; Xiaoyu Ren, Xiaokang Shi, Sizhuo Yang, Xiai Gao, and Guosheng Huang*, On Water: Free Catalysis Approach for the Synthesis of Nitrones from Hydroxamic Acids and Dimethy, Chin. J. Chem., 2013, 31, 1003.

[15] Zhu, Y.; Huang, H.-Y.; Yong-Qin He; Wang, M.; Wang, X.-Y.; Song, X.-R.; Mao, Z.-J.; Tian, W.-F*.; Xiao, Q. Visible-light enabled photochemical reduction of 1,2-dicarbonyl compounds by Hünig's base. Org. Chem. Front. 2022, 9, 1924-1931.

[16] Tian, W.-F.; Zhu, Y.; Yong-Qin He; Wang, M.; Song, X.-R.; Bai, J.; Xiao, Q*. Hydroxyl Assisted, Photoredox/Cobalt Co-catalyzed Semi-Hydrogenation and Tandem Cyclization of o-Alkynylphenols for Access to 2,3-Dihydrobenzofurans. Adv. Synth. Catal. 2021, 363, 730-736.

[17] Xingxing Liu, Zhaoyang Wu, Yong-Qin He; Xiaoqiang Zhou, Ting Hu, Chaowei Ma, and Guosheng Huang*, Copper-Catalyzed C-N Bond Formation via Oxidative Cross-Coupling of Amines with α-Amino Carbonyl Compounds, Adv. Synth. Catal., 2016, 358, 2385.

[18] Xiaoqiang Zhou, Hao Yan, Chaowei Ma, Yong-Qin He; Yamin Li, Jinhui Cao, Rulong Yan*, and Guosheng Huang*, Copper-Mediated Aerobic Oxidative Synthesis of 3 Bromoimidazo[1,2 a]pyridines with Pyridines and Enamides, J. Org. Chem., 2016, 81, 25.

[19] Xingxing Liu, Zhaoyang Wu, Xinliang Luo, Yong-Qin He; Xiaoqiang Zhou, and Guosheng Huang*, PhI(OAc)2 Oxidative C(5) Halogenation of Quinolines Using Copper Halides Under Mild Conditions, RSC Adv., 2016, 6, 71485.

[20] Yamin Li, Xiaoqiang Zhou, Zhaoyang Wu, Jinhui Cao, Chaowei Ma, Yong-Qin He; and Guosheng Huang*, Metal free synthesis of 2,4-diarylquinoline derivatives with enamides and imines, RSC Adv., 2015, 5, 88214.

[21] Haojie Ma, Xiaoyu Ren, Xiaoqiang Zhou, Chaowei Ma, Yong-Qin He; and Guosheng Huang*, Palladium and copper co-catalyzed Markovnikov hydrothiolation of terminal olefins and alkynes, Tetrahedron Lett., 2015, 56, 6022.

3、成果获奖:

麦曦,欧阳婷,涂国刚,贺永勤,廖一静,冯丽华,赵天生,李娜,付敏,曾祥盛,江西省科学技术进步二等奖,新型无过渡金属参与的偶联反应体系在化学药制备中的应用及产业化,2021,8/10

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